About TFBS

Dr Ryu is the Vice President of TFBS BIOSCIENCE, LLC and is responsible for the general business management of TFBS Japan. He has over 30 years of experience in translational medicine, clinical development, and R&D strategy planning in global R&D centers such as Pfizer, GSK, Takeda, and Ono. 

Dr Ryu graduated from Kaohsiung Medical University. He received his PhD from Kyushu University and was a research fellow at Georgia State University.

Dr. Li is Senior Manager of Testing Department responsible for in vivo studies.  Many of the pre-clinical projects Dr. Li worked on have progressed into clinical testing including several promising vaccine candidates that are currently in clinical trials. Prior to joining TFBS, Dr. Li was a post-doctoral fellow at the Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Department of Physiology, National Cheng Kung University in various functions of the cardiovascular regulation mechanism by diseased models. She was awarded the 2014 “APSN Young Investigator Colloquium” at the 12th Meeting of the APSN, for her research achievement in blood pressure regulation after a stroke. Dr. Li has extensive research experience in diseased animal model development which have led to preclinical study.

Dr. Li received her B.S. and M.S. in Biological Sciences from National Sun Yat-sen University, and her Ph.D. in Pharmacology from National Yang-Ming University, Taipei.

Dr. Yuan is Chairman and Chief Executive Officer for TFBS.

Before founding TFBS in 2016, Dr. Yuan was Vice-President of Development Center of Biotechnology (DCB) in Taiwan, responsible for drug discovery and development. During his 12-year tenure at DCB, Dr. Yuan had leadership roles over various research activities from drug design, assay development, pharmacology, to preclinical development. Prior to joining DCB, Dr. Yuan assumed research positions in the HCV Group at Roche Pharmaceutical in Palo Alto, and in the Gene Therapy Division of Berlex Bioscience in Richmond, California. Dr. Yuan has completed his academic training as a postdoctoral fellow at University of Texas, Medical Branch in Galveston, after obtaining a doctorate degree in Biochemistry from University of Pennsylvania.

Esther Chiu is Senior Manager of Quality Assurance department in TFBS, Head of Quality Assurance for contract analysis group and viral vector manufacturing group.

Master of Science, University of Birmingham, UK, Applied Genetics

She brings over nearly 20 years of experience in the GMP pharmaceutical company and over 8 years of experience in biopharmaceutical industry spanning leadership roles in both private and public large pharmaceutical as well as small biotech companies.

Familiar with GMP manufacturing quality guideline from investigational status to post market.

As an AP of sterile product releasing, more than 500+ batches.

International Authority Inspection experience, FDA, EU, TFDA, KFDA clinical stage (QP inspection), pre-approval inspection and follow-up inspection were approved.

International client inspection GSK, Pfizer

Mycenax, Sunny Pharmtech Inc., UBI Pharma Inc., Synmosa

Man-Shiow has 25 years of experiences of the field biologics production including 10 years of the viral vector production. 

Prior to joining TFBS, Man-Shiow led the viral vector process technology development at WuXi AppTec and Vigene Biosciences. She also served for NIH, NCI and a couple of private companies, which she mainly focused on the downstream process development of proteins, virus  and antibodies drug substance purification 

Man-Shiow received her Ph.D. degree from the Johns Hopkins University, school of Medicine, BCMB program.

With lifelong passion for virus-based gene delivery, Dr. Pei-Yu Wu assumes the research and development mission of TFBS as a solid support to TFBS’s viral vector manufacturing services. Dr. Wu is a molecular and cellular biologist with extensive research experience on many aspects of biomedical science, ranging from protein signal-transduction, innate immunity and inflammatory responses, DNA damage and genomic instability, viral-host interactions, to translational mouse model for cancer therapeutics. His particular know-hows include design of mammalian expression and virus package plasmid vectors (e.g., episomal, Lentiviral, and γ-retroviral vectors), cell line establishment (e.g., cell adaptation, cloning, sorting, and stable expression), protein engineering (e.g., functional mutation, surface expression, recombinant ScFv, and directed evolution), microscopic assessment (e.g., confocal microscopy, and laser micro-irradiation), and next-generation sequencing analysis. Prior to TFBS, Dr. Wu worked as a senior research scientist in Taiwan protein project and a postdoctoral fellow at Academia Sinica for more than a decade, where he took cumulating responsibilities for managing laboratory and research projects, and training 5 Ph.D. students. As results of these works, he is the author of 16 peer-reviewed publications with several first and corresponding authorships, and holds issued patents in US and Taiwan.

Dr. Wu received his Ph.D. degree in cancer biology from L’Université Toulouse III – Paul Sabatier, France, and his M.Sc. degree in veterinary medicine and B.Sc. degree in zoology, both from National Chung-Hsing Universiy, Taiwan.

Shao-Hua Lo is currently Director of Business Development Department responsible for global sales and marketing. Mr. Lo has more than ten years of leadership experiences in the field of quality, testing and business development with an emphasis on biologics and advanced cellular and gene therapies. He was previously Senior Manager of Testing department at TFBS Bioscience, where he was responsible for the operation of testing facilities for the contract research organization (CRO). He has accomplished more than hundreds of domestic and global projects including tech-transfer, validation and analysis of phase I/II/III derived biologics and regenerative medicines overseas. Prior to joining TFBS Bioscience, Mr. Lo held study director and associate research fellow positions at Institute of Biologics in Development Center for Biotechnology (DCB).

Mr. Lo holds a master and bachelor degree in Biomedical Engineering and Environmental Science from National Tsing Hua University in Taiwan.